Table 2.
Nerve cell metabolic pathways from the interactome map designed by FunRich software. Genes, names and IDs of proteins identified or not detected from EVs proteomic analyses are reported in black and red, respectively.
| Pathway | Genes | Protein name | Protein ID |
|---|---|---|---|
| Axon guidance | AP2B1, MYH9, GRB2, SPTAN1, SPTBN1, CLTC, EGFR, YWHAB, CDC42, HRAS | AP-2 complex subunit beta, Myosin-9, Growth factor receptor-bound protein 2, Spectrin alpha chain, non-erythrocytic 1, Spectrin beta chain, non-erythrocytic 1, Clathrin heavy chain 1, Epidermal growth factor receptor, 14-3-3 protein beta/alpha, Cell division control protein 42 homolog, GTPase HRas | P63010, P35579, P62993, Q13813, Q01082, Q00610, P00533, P31946, P60953, P01112 |
| Signalling NGF | HRAS, YWHAB, CLTC, GRB2, YWHAE, AP2B1, TRAF6 | GTPase Hras, 14-3-3 protein beta/alpha, Clathrin heavy chain 1, Growth factor receptor-bound protein 2, 14-3-3 protein epsilon, AP-2 complex subunit beta, TNF receptor-associated factor 6 |
P01112, P31946, Q00610,P62993, P62258, P63010, Q9Y4K3 |
| TGF-B receptor signalling | HSPB1, MAPK13, YWHAZ,MAP3K3, YWHAG, GRB2, SPTBN1, SFN, MAP3K1, CTNNB1, ARRB2, TRAF6, RAN, MYC, YWHAE, YWHAB, YWHAQ, HSPA8, CDC42. | Heat shock protein beta-1, Mitogen-activated protein kinase 13, 14-3-3 protein zeta/delt, Mitogen-activated protein kinase kinase kinase 3, 14-3-3 protein gamma, Growth factor receptor-bound protein 2, Spectrin beta chain-non-erythrocytic 1, 14–3-3 protein sigma, Mitogen-activated protein kinase 1, Catenin beta-1, Beta-arrestin-2, TNF receptor-associated factor 6, GTP-binding nuclear protein Ran, Myc proto-oncogene protein, 14-3-3 protein epsilon, 14-3-3 protein beta/alpha, 14-3-3 protein theta, Heat shock cognate 71 kDa protein, Cell division control protein 42 homolog | P04792, O15264, O15264, Q99759, P61981, P62993, Q01082, P31947, Q13233, P35222, P32121, Q9Y4K3, P62826, P01106, P62258, P31946, P27348, P11142, P60953 |
| Neuronal system | AP2B1, ACTN2, HSPA8,HRAS | AP-2 complex subunit beta, Alpha-actinin-2, Heat shock cognate 71 kDa protein, GTPase HRas | P63010, P35609, P11142, P01112 |
| Neurotrophic | YWHAZ, YWHAG, SFN, DNM1, GRB2, HRAS, YWHAE, YWHAB, YWHAQ, CDC42 | 14-3-3 protein zeta/delta, 14-3-3 protein gamma, 14-3-3 protein sigma, Dynamin-1, Growth factor receptor-bound protein 2, GTPase Hras, 14-3-3 protein epsilon, 14-3-3 protein beta/alpha, 14-3-3 protein theta, Cell division control protein 42 homolog |
P63104, P61981, P31947, Q05193,P62993, P01112, P62258, P31946, P27348, P60953 |
| NCAM signalling for neurite outgrowth | GRB2, SPTAN1, SPTBN1, HRAS, YWHAB | Growth factor receptor-bound protein 2, Spectrin alpha chain, non-erythrocytic 1, Spectrin beta chain, non-erythrocytic 1, GTPase Hras, 14-3-3 protein beta/alpha | P62993, Q13813, Q01082, P01112, P31946 |