Table 4.
Multivariate cox regression analysis for primary and composite endpoints.
| Model | Renal progression (event/total = 82/331) |
All-cause mortality (event/total = 31/331) |
Composite endpoint (event/total = 100/331) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | HR | 95% CI | p | |
| Diabetes mellitus (yes vs. no) | |||||||||
| unadjusted | 6.155 | 3.819–9.921 | <.001 | 1.871 | 0.917–3.821 | .085 | 2.773 | 1.822–4.221 | <.001 |
| #adjusted | 3.675 | 1.975–6.835 | <.001 | 1.609 | 0.539–4.808 | .394 | 1.986 | 0.732–5.390 | .178 |
| Hypertension (yes vs. no) | |||||||||
| unadjusted | 2.541 | 1.466–4.406 | .001 | 1.186 | 0.567–2.482 | .65 | 1.196 | 0.736–1.944 | .47 |
| #adjusted | 1.343 | 0.658–2.741 | .418 | 1.233 | 0.435–3.494 | .694 | 1.403 | 0.527–3.737 | .498 |
| Hs-CRP (1 mg/L) | |||||||||
| unadjusted | 1.000 | 0.983–1.018 | .964 | 1.017 | 1.007–1.027 | .001 | 1.014 | 1.002–1.026 | .022 |
| #adjusted | 0.997 | 0.967–1.028 | .838 | 1.007 | 0.974–1.042 | .663 | 1.006 | 0.973–1.040 | .734 |
| Uric acid (1 mg/L) | |||||||||
| unadjusted | 1.207 | 1.095–1.329 | <.001 | 1.303 | 1.127–1.507 | <.001 | 1.314 | 1.152–1.499 | <.001 |
| #adjusted | 0.962 | 0.765–1.209 | .739 | 1.419 | 0.808–1.633 | .439 | 1.130 | 0.817–1.562 | .461 |
| Proteinuria (1 g/day) | |||||||||
| unadjusted | 1.445 | 1.344–1.554 | <.001 | 1.264 | 1.082–1.477 | .003 | 1.290 | 1.130–1.472 | <.001 |
| #adjusted | 1.387 | 1.259–1.528 | <.001 | 1.264 | 0.975–1.638 | .077 | 1.285 | 1.031–1.600 | .026 |
| Chronic MS pain (yes vs. no) | |||||||||
| unadjusted | 1.004 | 0.649–1.555 | .984 | 1.045 | 0.515–2.120 | .903 | 1.054 | 0.710–1.565 | .794 |
| #adjusted | 1.428 | 0.795–2.564 | .233 | 2.912 | 1.004–8.444 | .049 | 2.326 | 0.878–6.161 | .089 |
| NSAID usage (yes vs. no) | |||||||||
| unadjusted | 0.580 | 0.231–1.455 | .246 | 0.491 | 0.066–3.667 | .488 | 0.813 | 0.191–3.471 | .780 |
| #adjusted | 0.736 | 0.218–2.481 | .621 | 0.473 | 0.061–3.671 | .474 | 0.862 | 0.191–3.900 | .847 |
| Chinese Herb usage (yes vs. no) | |||||||||
| unadjusted | 1.095 | 0.522–2.297 | .810 | 1.949 | 0.663–5.731 | .226 | 1.083 | 0.557–2.104 | .814 |
| #adjusted | 0.752 | 0.270–2.092 | .585 | 2.368 | 0.625–8.972 | .205 | 1.685 | 0.459–6.180 | .431 |
#adjusted for age (1-year increment), male gender, diabetes status, hypertension status, eGFR (1 mL/min increments), serum hemoglobin (1 g/dL increments), albumin (1 g/L increments), hs-CRP (1 mg/L increments), calcium (1 mg/dL increments), phosphate (1 mg/dL increments), Ca × P (1 mg2/dL2 increments), proteinuria (1 g/day).
MS: musculoskeletal; NSAID: nonsteroidal anti-inflammatory drug.