Table 7.
Overview on academic phase III/IV ATMP clinical trials (Stem cell transplantation for haematological malignancies not included).
| Trial Identifier | Phase | Sponsor | Product/Procedure | Indication |
|---|---|---|---|---|
| NCT00434616 | III | Franziskus-Krankenhaus | Autologous bone marrow cells | Critical limb ischemia |
| NCT01803347 | III | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | Autologous expanded adipose-derived stem cells | Anal fistula |
| NCT01569178 | III | Queen Mary University of London | Bone marrow derived mononuclear cells | Acute myocardia infarction |
| NCT03477500 | III | NCT03477500 Haukeland University Hospital | Autologous stem cells | Multiple sclerosis |
| ISRCTN54371254 | III | EBMT Central Office | Autologous hematopoietic stem cells | Diffuse cutaneous systemic sclerosis |
| EUDRACT2015-000431–32 | III | Universidad Autónoma de Madrid (U.A.M.) | Autologous human bone marrow-derived expanded mesenchymal stromal cells | Diaphyseal metaphyseal fracture and non union |
| n/a | III | Unknown | Renal cell tumor vaccine | Renal carcinoma |
| NCT00297193 | III | European Group for Blood and Marrow Transplantation | The Broad Foundation | Autologous Stem Cells | Cohn’s Disease |
| NCT02437708 | III | Universitaire Ziekenhuizen Leuven | Stem cells | Periapical bone healing in infected immature primary teeth |
| NCT01818310 | II|III | University Hospital Ostrava|Ministry of Health, Czech Republic|Regional Council of the Moravian-Silesian region, KU MSK | Autologous Bone Marrow Aspirate Concentrate | No-Option Critical Limb Ischemia |
| NCT02849613 | II|III | University Hospital, Grenoble | Regenerative Stem Cell Therapy | Stroke |
| NCT00904501 | III | CHU de Reims |Etablissement Francais du Sang | Bone Marrow Autograft | Limb Ischemia |
| NCT03325504 | III | Universidad Autonoma de Madrid | Mesenchymal stem cells + Biomaterial | Bone Healing in Non-Union |
| NCT01489501 | III | CellSeed France S.A.R.L.|FGK Clinical Research GmbH | Oral mucosal epithelial cell sheet | Limbal Stem Cell Deficiency |
| NCT00938847 | III | Asklepios proresearch Cordis Corporation | Bone Marrow Derived Mononuclear | Myocardial Regeneration |
| NCT01983748 | III | University Hospital Erlangen | Dendritic Cells Plus Autologous Tumor RNA | Uveal Melanoma |
| NCT01693042 | II|III | Johann Wolfgang Goethe University Hospital | Autologous Bone Marrow-derived Mononuclear Cells | Chronic Post-infarction Heart Failure |
| NCT01753440 | II|III | AHEPA University Hospital | Allogeneic Stem Cells Implantation Combined With Coronary Bypass Grafting | Ischemic Cardiomyopathy |
| NCT01759212 | II|III | AHEPA University Hospital | Left Ventricular Assist Device + Allogeneic Mesenchymal Stem Cells Implantation | End-stage Heart Failure |
| NCT03112122 | IV | Istituto Ortopedico Rizzoli | Bone Marrow Concentrate | Bone Marrow Edema |
| NCT03110679 | IV | Istituto Ortopedico Rizzoli | Autologous Bone Marrow Concentrate | Osteoarthritis |
| NCT02454231 | II|III | University of Florence|Tuscany Region | Stem Cells | Life Threatening Limbs Arteriopathy |
| NCT00539266 | II|III | Leiden University Medical Centre | Autologous Bone Marrow-derived Mononuclear Cells | Limb Ischemia |
| NCT03042572 | II|III | The Netherlands Organisation for Health Research and Development|UMC Utrecht | Allogeneic Mesenchymal Stromal Cells | No-option Ischemic Limbs |
| NCT01343836 | II|III | Erasmus Medical Center | Autologous Tenocyte Implantation | Chronic Achilles Tendinopathy |
| NCT03229564 | II|III | University of Zurich|ETH Zurich (Switzerland)|Julius Clinical, The Netherlands | Autologous Dermo-epidermal Skin Substitute | Treatment of Burns in Children |
| NCT02323620 | III | American Heart of Poland | Bone marrow derived mononuclear cells | Myocardial infarction |
| NCT03404063 | II|III | John Paul II Hospital, Krakow|KCRI|National Center for Research and Development, Poland | CardioCell (Wharton´s Jelly derived mesenchymal stem cells) | Acute Myocardial Infarction |
| NCT03423732 | II|III | John Paul II Hospital, Krakow|KCRI|National Center for Research and Development, Poland | CardioCell (Wharton´s Jelly derived mesenchymal stem cells) | No-option Critical Limb Ischemia |
| NCT02248532 | II|III | University Medical Centre Ljubljana | CD34+ Cells | Dilated Cardiomyopathy |
| NCT02144987 | IV | Instituto Valenciano de Infertilidad, IVI VALENCIA | Bone Marrow Stem Cells | Asherman’s Syndrome and Endometrial Atrophy |
| NCT03535480 | IV | Instituto de Investigacion Sanitaria La Fe | Autologous Bone Marrow Stem Cells | Premature Ovarian Failure |
| NCT02389010 | III | Centro Nazionale Sangue|Italian National Cord Blood Network | Platelet Gel From Cord Blood | Diabetic Foot Ulcers |
| NCT00747708 | II|III | Barts & The London NHS Trust | Bone Marrow Derived Adult Stem | Chronic Heart Failure |