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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Glia. 2018 Dec 24;67(5):802–824. doi: 10.1002/glia.23568

Figure 8. HIV ssRNA40 promotes mitochondrial damage and PINK1-Parkin, and autophagy receptors p62 and OPTN recruitment in microglia cells.

Figure 8

(a and b) Intracellular distribution of PINK1 and Parkin in HMG (a) and HFMG (b) cells stimulated with ssRNA40 for 24h examined by confocal microscopy. Arrow: PINK1 and Parkin co-localization (yellow puncta) in enlarged image (c) Representative immunofluorescent images showing intracellular distribution of SQSTM1 (green) and Parkin (red) in HMG (left) and HFMG (right) cells stimulated with ssRNA40 for 24h. Arrow: SQSTM1 and Parkin co-localization (yellow puncta) in enlarged image (d) Intracellular distribution of OPTN (red) and mitochondria (green, Tom20) following 24h stimulation with ssRNA40 in HMG (left) and HFMG (right) cells. Arrow: Tom20 and OPTN co-localization (yellow puncta) in enlarged image. Scale bar indicates 10µm. Data are representative of three independent donors (n=3).

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