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. 2012 Jan 26;18(1):4–13. doi: 10.1111/j.1755-5949.2011.00276.x

Figure 4.

Figure 4

d‐Serine potentiates neuronal differentiation of NSCs. (A and B) d‐Serine (100 μM) significantly promoted the neuronal differentiation of NSCs. Either dAAO (0.1 U/mL) or MK‐801 (10 or 30 μM) prevented the neuronal differentiation remarkably, whereas compared with control group, no significant effect on the differentiation was detected in the presence of NaBZ. n = 5. *P < 0.05 as compared with the control group. Scale bar = 100 μM. (D and E) d‐Serine (100 μM) or NaBZ (20 μM) could alleviate dAAO‐induced prohibition of neuronal differentiation of NSCs. d‐Serine (100 μM) could also alleviate MK‐801‐induced inhibition of neuronal differentiation. n = 5. *P < 0.05 as compared with the control group, #P < 0.05 as compared with the dAAO‐treated group and $ with 10 μM MK‐801‐treated group. Scale bar = 100 μM. (C and F) On the other hand, dAAO, d‐serine, MK‐801, and NaBZ had no influence on the proportion of GFAP+ cells.