Figure 1.

Rotenone suppressed basal synaptic transmission in concentration‐ and time‐dependent manners. Basic field excitatory postsynaptic potentials (fEPSPs) were recorded from the hippocampal CA1 region following repetitive stimulation (100 μs, 0.03 Hz for 60 min) of Schaffer collaterals. Stimulation intensity was set to that which induced 50% of the maximal response. Representative typical traces evoked by single stimulation in the absence or presence of different concentrations of rotenone are shown (A–C). Summary of the concentration‐dependent inhibition of basal fEPSPs by rotenone is shown (D). Each symbol represents the average from 6–12 slices (from 4–8 rats), and the vertical bars represent ±SE. **P < 0.01 when comparing evoked responses under control conditions versus 500 nM rotenone between 70–80 min (horizontal bar).