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. 2012 Jun 22;18(8):674–682. doi: 10.1111/j.1755-5949.2012.00348.x

Figure 2.

Figure 2

The comparative analysis results of stroke‐related gene expression profiles among jasminoidin‐, ursodeoxycholic acid‐, and the combination‐treated groups. (A) Cluster analysis of altered genes among the 3 treatment groups, which indicates that the profiles of gene expression in jasminoidin (JA)‐ and the combination (JA + UA)‐treated groups have some similarities, compared with those of ursodeoxycholic acid (UA)–treated group. (B) Principal components analysis (PCA) of altered genes among jasminoidin‐, ursodeoxycholic acid‐, and the combination‐treated groups, which shows the data in jasminoidin (blue)‐, ursodeoxycholic acid (red)‐, and the combination‐treated (green) groups are clustered, respectively, and the combination and jasminoidin‐treated groups are relatively close to each other. (C) Up‐regulated differentially expressed genes overlapping and nonoverlapping among the 3 treatment groups, which shows that (1) 11 up‐regulated differentially expressed genes overlapped among the 3 groups; (2) 10 up‐regulated differentially expressed genes overlapped between jasminoidin‐ and the combination‐treated groups, only 1 up‐regulated differentially expressed gene overlapped between ursodeoxycholic acid‐ and the combination‐treated groups, and 11 up‐regulated differentially expressed gene overlapped between jasminoidin‐ and ursodeoxycholic acid–treated groups; (3) 3, 15, or 5 differentially expressed genes were only up‐regulated in jasminoidin‐treated, ursodeoxycholic acid–treated, or combination‐treated group, respectively. (D) Down‐regulated differentially expressed genes overlapping and nonoverlapping among the 3 treatment groups, which demonstrated that (1) only 1 down‐regulated differentially expressed gene overlapped among the 3 groups; (2) none down‐regulated differentially expressed gene overlapped between jasminoidin‐ and the combination‐treated groups or between ursodeoxycholic acid‐ and the combination‐treated groups, and 4 down‐regulated differentially expressed genes overlapped between jasminoidin‐ and ursodeoxycholic acid–treated groups; (3) 10, 9, or 1 differentially expressed genes were only down‐regulated in jasminoidin‐treated group, ursodeoxycholic acid–treated or, combination‐treated group, respectively.