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. 2012 Dec 20;19(2):117–124. doi: 10.1111/cns.12043

Figure 2.

Figure 2

Diammonium glycyrrhizinate (DG) reduces the inflammatory factors in Aβ1–42‐induced AD mice. The mRNA levels of TNF‐α (A), COX‐2 (B), iNOS (C), IL‐1b (D), and IL‐10 (E) were determined by real‐time PCR. (F)The protein levels of COX‐2 and iNOS were determined by Western blotting. The relative mRNA and protein levels of normal mice were set as 1. Con: normal mice; DG: normal mice with DG (10 mg/kg per day, i.p. for 14 days); Aβ: Aβ1–42‐induced AD mice; Aβ+DG: Aβ1–42‐induced AD mice with DG (10 mg/kg per day, i.p. for 14 days). n = 4 mice per group. *: P < 0.05 versus Control; **: P < 0.01 versus Control; #: P < 0.05 versus Aβ1–42‐induced AD mice; ##: P < 0.01 versus Aβ1–42‐induced AD mice.