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. 2013 Feb 14;19(4):262–268. doi: 10.1111/cns.12066

Figure 1.

Figure 1

Effect of artemisinin on neuritic plaque formation in APPswe/PS1dE9 double transgenic mice. APPswe/PS1dE9 transgenic mice aged 5 months were treated with 40 mg/kg artemisinin (Art) for 30 days, whereas age‐matched control APPswe/PS1dE9 mice received vehicle solution (Ctrl) as control. The mice were killed, and the brains were dissected, fixed, and sectioned. (A) Neuritic plaques were detected by immunohistochemistry using an Aβ1‐42 antibody. The plaques were visualized by microscopy with 200× magnification. Artemisinin significantly reduced the numbers of neuritic plaques in the cortex (Cort) and hippocampus (Hippo) of mice compared with controls. Black arrows point to plaques. Bars: 100 μm. (B) Quantification of neuritic plaques in APPswe/PS1dE9 mice in each group. An ELISA was conducted to measure brain‐soluble Aβ42 (C) and brain‐insoluble Aβ42 (D) levels in transgenic mice in each group. The numbers represent the mean ± SEM. n = 4 mice each (for immunohistochemistry). n = 3 mice each (for ELISA). *P < 0.05 by Student's t‐test.