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. 2013 Feb 14;19(4):262–268. doi: 10.1111/cns.12066

Figure 3.

Figure 3

Effect of artemisinin on APP processing pathways in APPswe/PS1dE9 double transgenic mice. (A) Brain tissues from APPswe/PS1dE9 mice were subjected to Western blotting to determine the levels of APP‐full length (FL), BACE1, PS1, Aph‐1a, and APP‐CTFs, with β‐actin as a loading control. (B) Quantification of APP‐FL, BACE1, PS1, Aph‐1a, and APP‐CTFs in brain tissues. Artemisinin significantly decreased BACE1 expression and had no influence on the levels of APP‐FL, PS1, Aph‐1a, and APP‐CTFs. n = 3. *P < 0.05 by Student's t‐test.