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. 2012 Oct 29;18(11):918–926. doi: 10.1111/cns.12011

Figure 2.

Figure 2

Cholinergic tone is diminished in rats with Sinoaortic denervation (SAD). (A) In male SD rats (350–400 g) with intact but varying degrees of arterial baroreflex function. The cholinergic tone was expressed as the changes of heart period induced by atropine sulfate (0.03 mg/kg, iv) in conscious, freely moving rats, n = 25. The relationships between the peripheral cholinergic tone and the baroreflex sensitivity (BRS) are assessed by univariate regression analysis. The Pearson r‐values were calculated. (B, C, D) SAD decreased the rate of spontaneous discharge. Single‐unit extracellular recording was made in nucleus ambiguous (NA) on both sides. The site of extracellular recording in NA is shown in B. Data are expressed as mean ± SD.*P < 0.05, **P < 0.01. Student's t‐test. n = 5–7. Neurons for each rats, n = 5 in each group. (E) SAD decreased the change of heart period induced by atropine sulfate. The systolic blood pressure (SBP) had no change. Data are expressed as mean ± SD.*P < 0.05, **P < 0.01. Paired Student's t‐test. n = 9–11 in each group.