Figure 1.

Illustration of the Morris water maze (MWM) training protocol. (A) Wild‐type (WT) and AQP4 knockout (KO) mice were first trained to find the hidden platform (placed in the center of training quadrant) by four trials daily for 9 days and tested by the probe trial on day 10. Starting from day 11, the same animals were subjected to the cued platform training, during which the platform was moved from training quadrant to the opposite quadrant (as illustrated). Animals were trained by four trials daily for 2 days (from day 11 to day 12). (B) WT and AQP4 KO mice were trained to swim without the platform similar to the session of the MWM. TQ, training quadrant; AR, adjacent right quadrant; AL, adjacent left quadrant; OP, opposite quadrant.