Skip to main content
. 2013 Mar 25;19(4):235–243. doi: 10.1111/cns.12069

Figure 1.

Figure 1

Resolvin D1 (RvD1) prevents lipopolysaccharide (LPS)‐induced inflammatory responses in murine microglial cells. The LPS‐activated microglial cells induce the release of pro‐inflammatory factors and cytokines through the interaction of LPS and TLR4. RvD1 attenuate inflammatory responses through ALX receptors that match the regulation of c‐jun N‐terminal kinase (JNK), p38 mitogen‐activated protein kinase (MAPK), NF‐κ B, et al. Overall, RvD1 inhibited microglial activation and migration by suppressing the release of inflammatory mediators induction of stop signal which negatively regulate MAPKs and NF‐κ B.