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. 2013 Mar 25;19(4):235–243. doi: 10.1111/cns.12069

Figure 6.

Figure 6

Resolvin D1 (RvD1) inhibits the nuclear translocation of nuclear factor‐κB (NF‐κB) p65. Electrophoretic mobility shift assay was used to analyze the inhibition of nuclear translocation of NF‐κB followed by cells were incubated with 100 ng/mL lipopolysaccharide (LPS) for 0, 30, 60, and 120 min. (A) The p65 subunit gradually and significantly transferred to the nucleus in the presence of LPS‐induced cells for 60 min. Given the fact that LPS induce the nuclear translocation of NF‐κB within a certain time range. (B) Also, the experimental effect of pretreatment of RvD1, LPS, and RvD1 + LPS on nuclear translocation of p65 was examined, and pretreatment of RvD1 for 30 min significantly inhibited LPS‐induced nuclear translocation.