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. 2013 Mar 25;19(4):222–228. doi: 10.1111/cns.12075

Figure 1.

Figure 1

(A) The intracortical injection of penicillin (500 IU) induced epileptiform activity on ECoG. (B) The intracerebroventricular (i.c.v.) administration of leptin, at a dose of 1 μg, increased the mean frequency of penicillin‐induced epileptiform activity without changing the amplitude. (C) Administration of the CB1 receptor antagonist, AM‐251 (i.c.v.), at a dose of 0.25 μg, caused a marked increase in the frequency of penicillin‐induced epileptiform activity within 30 min after AM‐251 injection. (D) Administration of the CB1 receptor agonist, ACEA (i.c.v.), at a dose of 7.5 μg, significantly decreased the mean frequency of epileptiform activity within 50 min after ACEA injection. (E) The administration of AM‐251 (0.25 μg, i.c.v.) 10 min after leptin injection (1 μg, i.c.v.) increased the frequency of epileptiform activity within 40 min after leptin injection. (F) The administration of leptin (1 μg, i.c.v.) 10 min before ACEA (7.5 μg, i.c.v.) injection fully inhibited the anticonvulsant effects of ACEA. (G) Baseline ECoG activity before penicillin or the injection of other substances. Representative ECoGs are presented for the 120 min after penicillin administration.