Table 2. Top-40 potential peptide-HLA complexes for top-15 candidate TSAs binding to HLA-A*02.
| Gene | Peptide | IC50 (nM) | Strong/weak binders | |
|---|---|---|---|---|
| 1 | ACTL8 | KMLEILFEL | 2.18 | strong binder |
| 2 | MIA | LLAWAISPV | 3.95 | strong binder |
| 3 | ERVV-2 | ALPSLNWFV | 4.43 | strong binder |
| 4 | MAGEB4 | KVLEFLAKV | 6.26 | strong binder |
| 5 | ERVV-2 | FLFLYLSLL | 6.64 | strong binder |
| 6 | CLPSL1 | LLFFFLFLL | 8.2 | strong binder |
| 7 | DMBX1 | RLADIILEA | 8.34 | strong binder |
| 8 | ERVV-2 | YLSLLPMPL | 8.94 | strong binder |
| 9 | DMRT1 | SLFPYYNNL | 9.04 | strong binder |
| 10 | C6orf15 | GLFARSIGV | 9.14 | strong binder |
| 11 | CLPSL1 | FLLFFFLFL | 9.29 | strong binder |
| 12 | ERVV-2 | SLNWFVPLL | 10.3 | strong binder |
| 13 | MAGEB4 | LLMPLLSVI | 10.69 | strong binder |
| 14 | DMRT1 | MVIQDIPAV | 12.04 | strong binder |
| 15 | CT83 | KLVELEHTL | 12.24 | strong binder |
| 16 | CLPSL1 | LLFLLFFFL | 14.63 | strong binder |
| 17 | MIA | YMAPDCRFL | 14.71 | strong binder |
| 18 | C6orf15 | ALPEELSYL | 14.79 | strong binder |
| 19 | CLPSL1 | MMLPQWLLL | 17.12 | strong binder |
| 20 | CLPSL1 | MLPQWLLLL | 17.88 | strong binder |
| 21 | ERVV-2 | YLLAEQGGV | 18.37 | strong binder |
| 22 | MAGEB4 | GLLMPLLSV | 20.03 | strong binder |
| 23 | ERVV-2 | FLYLSLLPM | 20.03 | strong binder |
| 24 | C6orf15 | YLSSAAALA | 20.58 | strong binder |
| 25 | MAGEA6 | YIFATCLGL | 20.58 | strong binder |
| 26 | ERVV-2 | YILVRNFSL | 25.27 | strong binder |
| 27 | DMBX1 | YLGVNMAPL | 25.69 | strong binder |
| 28 | PRDM13 | KLYSRKYGL | 28.01 | strong binder |
| 29 | ERVV-2 | SLANSAHQV | 28.78 | strong binder |
| 30 | DMBX1 | GLAPASATL | 32.24 | strong binder |
| 31 | ERVV-2 | KITYSTPPV | 32.41 | strong binder |
| 32 | CT83 | ILNNFPHSI | 32.94 | strong binder |
| 33 | MAGEA6 | FLWGPRALI | 36.31 | strong binder |
| 34 | CT83 | YLLLASSIL | 38.12 | strong binder |
| 35 | C4orf51 | ILLPFSPLT | 42.94 | strong binder |
| 36 | MAGEA6 | KIWEELSVL | 45.09 | strong binder |
| 37 | PRDM13 | GLLKYPESI | 46.57 | strong binder |
| 38 | ERVV-2 | NLYTCINNI | 49.16 | strong binder |
| 39 | DMBX1 | HMAATNNLV | 52.74 | weak binder |
| 40 | CT83 | LLASSILCA | 53.9 | weak binder |