Table 1.
Weight changes due to psychotropics
| Medication | Percentage of patients having weight changes | Duration | Amount of weight gain |
|---|---|---|---|
| Olanzapine | 31%, 45–90% | 2.3 kg/month average. | |
| 4.2–7.4 kg total up to 12 kg | |||
| Quetiapine | 4.1–5.6 kg total | ||
| 1.8 kg/month | |||
| Risperdone | 1.0 kg/month | ||
| Ziprasidone | 0.8 kg/month | ||
| Asenapine | 3 weeks of treatment | 0.9 kg | |
| Ileperidone | 1.5–2.1 kg | ||
| Palipradone | – | 52 weeks | None |
| Aripiprazole | 0.5–0.9 kg weight gain total | ||
| Clozapine | Most likely to cause weight gain | 2.4–31.3 kg | |
| 1.7 kg/month | |||
| Imipramine | 10% | 3–4 kg | |
| Amitryptiline | 2 kg | ||
| Trazadone | 0.5–1.1 kg | ||
| Fluoxetine | Long term | 2–2.5 kg | |
| Citalopram | 1 year | 1–1.5 kg | |
| Fluvoxamine | No change in weight | ||
| Duloxetine | 8‐month trial | 0.61 kg | |
| Escitalopram | 1.83 kg | ||
| Divalproex | 71% of patients | 4 kg | |
| 0.9–14 kg | |||
| Lamotrigine | −2 kg or 0.6 kg weight gain | ||
| Carbamazepine | 15 kg | ||
| Lithium | 20% | 10 kg or 6.3 kg | |
| Zonasemide | 35% | Weight loss |