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Increased susceptibility to lithium–pilocarpine seizures after inhibition of glutamine synthetase (GS) activity. GS activity in the cortex (A) and hippocampus (B) was measured 24 h after methionine sulfoximine (MSO) administration. The seizure onset time (SOT) following lithium–pilocarpine injection was determined 24 h after MSO administration (C). Values are expressed as mean ± SEM. n = 3–6 (A, B); n = 5–7 (C). *P < 0.05, **P < 0.01 Compared with control.
