Figure 6.
Effects of chronic diphenhydramine treatment on glutamate and gamma aminobutyric acid (GABA) content after drug withdrawal in rats. Ten days after drug withdrawal from a 2‐week diphenhydramine (diphen) treatment, the total glutamate (Glu, A–C) and GABA (D–F) contents in the cortex (A, D), hippocampus (B, E), and thalamus (C, F) were determined by high‐performance liquid chromatography. Values are expressed as mean ± SEM. n = 5–7. *P < 0.05, **P < 0.01 Compared with control.