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Effects of pioglitazone on the Aβ40 and Aβ42 levels in the brain of STZ/HFD diabetic mice. Aβ40 (A) and Aβ42 (B) levels in the hippocampus and cerebral cortex were measured by ELISA assays. Immunohistochemistry of Aβ42 was also conducted and representative immunohistochemical microphotographs of Aβ42 are shown (C). Values are expressed as the mean ± SEM (n= 4). *P < 0.05 versus hippocampus of STZ/HFD+Veh group, # P < 0.05 versus cerebral cortex of STZ/HFD+Veh group.
