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Effects of pioglitazone on BACE1 content in the brain of STZ/HFD diabetic mice. Left panel is representative immunoblots of BACE1 and β‐actin (inner control) measured by western bloting using respective antibodies in hippocampus, left panel is immunoblots in cerebral cortex (A). Quantification of BACE1 is expressed as the ratio (in percentage) of control (B). **P < 0.01, ***P < 0.001 versus hippocampus of STZ/HFD+Veh group, ## P < 0.01 versus cerebral cortex of STZ/HFD+Veh group.
