Figure 6.

A speculated model for the roles of DNA methylation modification in Parkinson's disease. There might two ways that DNA methylation misregulation may play roles in PD. One is that at cellular level, it may influence the susceptibility of dopaminergic neurons to environmental neurotoxic factors, associating with the progressive loss of dopaminergic neurons in PD. Another is that at molecular level, it may misregulate transcription of key PD‐related genes such as α‐synuclein or TH, associating with the selective neurodegeneration of PD.