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. 2013 Oct 25;19(12):969–977. doi: 10.1111/cns.12198

Figure 5.

Figure 5

Angiogenesis was increased in aged mice with AAV‐APN gene transfer after tMCAO. (A) Photomicrographs showed the CD‐31 and PCNA double immunostaining in perifocal region in AAV‐APN transduced aged mouse brain 2 and 4 weeks after tMCAO. AAV‐APN transduced young adult mice and AAV‐GFP transduced aged mice were as control. Bar = 20 μm. (B) Bar graph showed the number of microvessels in AAV transduced aged and young adult mice. Values are mean ± SD, N = 6 in each group. **P < 0.01, APN versus GFP groups. (C) Bar graph showed that the number of microvessels between aged APN and young adult APN groups. **P < 0.01, aged APN versus young adult APN group. (D) Bar graphs showing the number of newly formed microvessels in the AAV‐APN transduced aged mice. Data are mean ± SD, n = 6 per group. **P < 0.01, APN versus GFP groups. (E) Bar graph showed that the number of microvessels between aged APN and young adult APN groups. Data are mean ± SD, n = 6 per group. *P < 0.05, aged APN versus young adult APN group. (F) Photomicrographs showed SMA‐positive cells in AAV‐APN transduced aged mouse brain 2 weeks and 4 weeks after tMCAO. (G) Bar graph showed the number of small arteries in the AAV‐APN transduced aged mice after 2 weeks and 4 weeks of tMCAO. Data are mean ± SD, n = 6 per group. **P < 0.01, APN versus GFP groups. (H) Bar graph showed that the number of small arteries between aged APN and young adult APN groups. Values are mean ± SD, N = 6 in each group. *P < 0.05, aged APN versus young adult APN group.