Effects of lithium and tamoxifen co‐administration on PSD‐induced hyperactivity. Each bar represents the mean of first, second and third repetition sessions (white, gray, and black bars, respectively) ± SEM across the three repetition sessions for 7 animals per group. *P < 0.01 compared with control conditions and the same pharmacological treatment. #P < 0.01 compared with vehicle group subjected to the same sleep conditions (three‐way ANOVA with repeated measures followed by the Newman–Keuls post hoc test). PSD, paradoxical sleep deprivation conditions; CTRL, control conditions; v, vehicle.