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. 2013 Jul 27;19(11):871–881. doi: 10.1111/cns.12144

Figure 3.

Figure 3

Effects of topiramate (TPM) and levetiracetam (LEV) on the transport of Aβ across the blood–brain barrier in APPswe/PS1dE9 double‐transgenic mice. An ELISA assay was conducted to measure brain soluble Aβ42 (Unit: pg/mg Protein) (A), insoluble Aβ42 (Unit: pg/mg Protein) (B), and peripheral blood Aβ42 (Unit: pg/mL) (C) levels in the brains of mice in each group. TPM, LEV, and valproic acid (VPA) significantly reduced soluble and insoluble Aβ42 levels in brain and increased the peripheral blood Aβ42 level. n = 3. *P < 0.05 by one‐way ANOVA. (D) Half brains from mice in each group were lysed in RIPA buffer. LRP1 and RAGE were detected by Western blotting using β‐actin as a loading control. (E) Quantification of LRP1 and RAGE in brains. TPM, LEV, and VPA significantly increased LRP1 expression, but exerted no significant effect on RAGE expression. n = 3. *P < 0.05 by one‐way ANOVA.