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Effects of chronic DHK treatment (10 μg, i.c.v., t.i.d, 5 days) with morphine (30 mg/kg, s.c., t.i.d., 5 days) on behavioral withdrawal signs in AQP4 knockout mice. Global scores (A), jumping,(B), writhing (C), rearing (D), and weight loss (E) were determined for 60 min after naloxone precipitation. Data are expressed as mean ± SEM. (ACSF group, n = 8; DHK group, n = 6). **P < 0.01 versus ACSF–morphine group, two‐way anova followed by Bonferroni post hoc test.
