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. 2012 Oct 11;19(1):12–19. doi: 10.1111/cns.12012

Figure 4.

Figure 4

Effects of repeated morphine treatment (30 mg/kg, s.c., t.i.d., 5 days) (A) and naloxone precipitation (5 mg/kg, i.p.) (B) on the extracellular levels of glutamate in the prefrontal cortex of wild‐type (WT) and AQP4 (KO) knockout mice. Data are expressed as mean ± SEM. (n = 6 per group). *P < 0.05, **P < 0.01 versus WT‐saline group; two‐way repeated measures anova followed by Bonferroni post hoc test. The first basal values of extracellular glutamate are as following: (A) WT‐saline: 1.07 ± 0.28 μm; WT‐morphine: 1.03 ± 0.17 μm; KO‐saline: 1.09 ± 0.24 μm; KO‐morphine: 1.11 ± 0.17 μm. (B) WT‐saline: 1.05 ± 0.22 μm; WT‐morphine: 1.10 ± 0.19 μm; KO‐saline: 1.17 ± 0.21 μm; KO‐morphine: 1.11 ± 0.13 μm.