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. 2012 Nov 22;19(1):53–60. doi: 10.1111/cns.12032

Figure 1.

Figure 1

Permanent brain ischemia induces neurovascular damage in rats. (A) Representative immunoblotting image showing spectrin and calcineurin expression following permanent middle cerebral artery occlusion (pMCAO) at the indicated times. (B) Representative immunoblots from the core and penumbra brain regions of pMCAO‐injured rats, as assayed using the indicated antibodies indicative of neurovascular damage. (C) The change in ZO‐1 expression in the core and penumbra brain regions of pMCAO rats. The asterisk indicates the 220‐kDa band of ZO‐1. (D) The changes in occludin expression in the core and penumbra brain regions of pMCAO rats. The asterisk identifies the high molecular weight band and the 65‐kDa band of occludin in sham and pMCAO rats.