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. 2019 Mar 20;124(9):1337–1349. doi: 10.1161/CIRCRESAHA.118.313788

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© 2019 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 2. — Characterization of human umbilical vein endothelial cell (HUVEC) super-enhancers (SEs) identifies enrichment for ERG (ETS-related gene) and ERG-target genes. A, HUVEC enhancer regions identified by H3K27ac and H3K4me1 were ranked by enrichment of H3K27ac chromatin immunoprecipitation with deep sequencing (ChIP-seq) signal in rpm/bp. SE clusters are shown to the right of the gray dashed line (see also Online Table V). B, HUVEC SE regions indicated as red bars above density plots of ERG ChIP-seq signal alongside H3K27ac at distal enhancers of VWF (von Willebrand factor), ICAM2, and ERG loci. C, Transcriptome profiling of HUVEC shows significantly higher gene expression in SE than in typical enhancers. ***P<0.0001, Wilcoxon rank-sum test. D, Gene set enrichment analysis of the top 500 SE-associated genes compared with the ranked gene list from transcriptome profiling of ERG-deficient HUVEC. Normalized enrichment score (NES)=2.13; P<0.001.