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. 2019 Mar 20;124(9):1337–1349. doi: 10.1161/CIRCRESAHA.118.313788

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© 2019 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 3. — ERG (ETS-related gene) defines super-enhancers (SEs) in human umbilical vein endothelial cells (HUVEC). A, ERG binding at SE and typical enhancer regions. SE have significantly more ERG bound than typical enhancers; ***P<0.0001, Fisher exact test. B, Scatterplot of the correlation between ERG and H3K27ac occupancy (log₂ transformed) in the 917 SE regions. Each point is the mean chromatin immunoprecipitation with deep sequencing signal across each SE region; P<0.001. C, SE ranked by ERG enrichment on identified enhancer regions. Known ERG-target genes proximal to SE are indicated (see also Online Table VI). D, Gene set enrichment analysis of the top 500 genes associated with ERG-identified SE compared with the ranked gene list from 917 H3K27ac-enriched SE. Normalized enrichment score (NES)=1.54; P<0.001. E, Gene ontology analysis was performed on the genes associated with SE identified by enrichment for H3K27ac or ERG. The top 7 biological processes ranked by significance (−log (P value)) are depicted.