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. 2019 Mar 20;124(9):1337–1349. doi: 10.1161/CIRCRESAHA.118.313788

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© 2019 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 8. — ERG (ETS-related gene) super-enhancers (SEs) prioritize cardiovascular disease (CVD) variants. A, Overlap of genome-wide association studies single nucleotide polymorphisms (SNPs) associated with disease trait classes within ERG-defined SE (orange) with chromosome and size-matched random SE (gray). Significance of enrichment was calculated by binomial distribution test with red dashed line indicating P=0.05. Some points overlay. B, Test for enrichment of selected CVD trait-associated SNPs within ERG-defined SE (orange) with chromosome and size-matched random SE (gray), as performed in A. Random region were restricted to open chromatin by excluding placement in repressed chromatin states in human umbilical vein endothelial cell.