Effect of systemic and local manipulation of NO signaling on the firing rate of dopaminergic SNc neurons. Representative rate histograms showing the effects elicited by i.p. administration (at arrows) of l‐NAME (50 mg/kg) (A), 7‐NI (50 mg/kg) (B), MOL (50 mg/kg) (C). APO, apomorphine administration (10 μg/kg i.v., at arrow). (D) Cumulative dose–response curve showing the mean percentage change (± SEM) in firing rate after vehicle, 7‐NI (50 mg/kg), l‐NAME (50 mg/kg), MOL (50 mg/kg) and l‐ARG (50 mg/kg).