Table 1.

Riluzole concentration for effects on neuronal firing

Current/channel	Effect (%)	Concentration (μM)	Tissue	Reference
Neuronal excitability
Firing frequency	Inhibition	6a	Cultured rat hippocampal neurons	[16]
Firing frequency	Inhibition	0.3a	Rat striatal neurons	[12]
Firing frequency	Inhibition	1.1a	Cultured embryonic rat spinal motor neurons	[17]
Firing frequency	Inhibition	0.52a	Rat neocortical neurons	[14]
Firing frequency	Inhibition	2–5	Rat facial motoneurons	[25]
Firing frequency	Inhibition (87%)	5	Rat carotid body chemoreceptor neurons	[52]
Firing frequency	Inhibition (25%)	0.75	Cultured embryonic G93A SOD1 mouse cortical neurons	[15]
Firing frequency	Inhibition (50%)	1	GH3 neuroendocrine cells	[35]
Evoked axonal fiber volley	Inhibition	7.5a	Rat CA3 hippocampal neurons	[89]

^aIC₅₀.