Table 3.

Effects of riluzole on voltage‐gated and other K⁺ currents and channels

Current/channel	Effect (%)	Concentration (μM)	Tissue	Reference
Potassium currents
Fast 1 component	Inhibition	21a	Frog myelinated nerve fiber	[58]
Fast 2 component	Inhibition	24a	Frog myelinated nerve fiber	[58]
Slow component	Inhibition	413a	Frog myelinated nerve fiber	[58]
Delayed rectifier K+ current	Inhibition	88a	Cultured embryonic rat cortical neurons	[41]
Voltage‐gated potassium channels
Mouse Kv1.1	Inhibition	92a	NIH/NT3 cells	[47]
Mouse Kv1.3	Inhibition	50a	NIH/NT3 cells	[47]
Rat Kv1.5	Inhibition	40a	CHO cells	[64]
Kv1.5	Inhibition (30%)	100	Rat vascular smooth muscle	[62]
Human Kv1.5	Inhibition	95a	MEL cells	[47]
Rat Kv3.1	Inhibition	124a	CHO cells	[64]
Human Kv3.1	Inhibition	95a	HEK‐293 cells	[47]
Rat Kv3.2	Inhibition	100a	COS‐7 cells	[47]
Kv1.4	Inhibition	70	Bovine adrenal zona fasiculata cells	[61]
Rat Kv4.2	Inhibition	130a	LTK cells	[47]
Rat Kv4.3	Inhibition	116.5a	CHO cells	[63]
HERG Kv11.1	Inhibition	50a	HEK‐293 cells	[47]
Two pore potassium channels
TRAAK	Activation (3.9 fold increase)	100	COS cells	[72]
TREK‐1	Activation (∼2 fold increase)	100	COS cells	[71]
TREK‐1	Activation	110b	Not stated	[47]
TREK‐1	Activation (3.3 fold increase)	100	Bovine adrenal zona fasciulata cells	[74]
THIK‐1	Inhibition (36%)	500	Mouse cerebellar Purkinje neurons	[75]
Calcium‐dependent potassium currents and channels
After hyperpolarization current	No effect	10	Cultured embryonic rat spinal motor neurons	[17]
After hyperpolarization current	Potentiation (70%)	3	Rat hippocampal pyramidal neurons	[16]
After hyperpolarizaton	No effect (amplitude)	1	GH3 neuroendocrine cells	[35]
	Increase (four‐fold in recovery time)
BK KCa	Activation	5b	GH3 neuroendocrine cells	[66]
BK KCa	Activation (30%)	10	GH3 neuroendocrine cells	[35]
BK KCa	Activation (2 fold increase)	5	Human retinal pigment epithelial cells	[67]
BK KCa	Activation (2 fold increase)	10	Human skeletal muscle cells	[50]
Human BK KCa1.1	Activation (2 fold increase)	100	HEK‐293 cells	[47]
Human SK1 KCa2.1	Activation (250 nM Ca2+)	21b	HEK‐293 cells	[47]
Rat SK2 KCa2.2	Activation (250 nM Ca2+)	12.8b	HEK‐293 cells	[47]
Human SK3 KCa2.3	Activation (250 nM Ca2+)	12.5b	COS‐7 cells	[47]
Rat SK3	Activation (2.3 fold increase, 100 nM Ca2+)	3	HEK‐293 cells	[68]
Human SK4 KCa3.1	Activation (250 nM Ca2+)	1.9b	HEK‐293 cells	[47]
Rat SK2 K(Ca)	Activation (Ca2+ free)	43b	HEK‐239 cells	[16]
	(100 nM Ca2+)	0.11b

^aIC₅₀.

^bEC₅₀.