Table 6.

Studies of riluzole effects in transgenic mice

G93A strain	Scott et al. (2008) High copy number	Guerney et al. (1996) High copy number	Guerney et al. (1998) High copy number	Snow et al. (2003) Low copy number	Waibel et al. (2004) High copy numbera	Del Signore et al. (2009) High copy number (?)
Dose	44 mg/kg in water	100 μg/mL in water	44 mg/kg in food	100 μg/mL in water	30 mg/kg in water	16 mg/kg in water
Started at (days)	50	50	42	40	60	30
Group size	35 (riluzole)	9 (riluzole)	11	14 (riluzole)	15	10
	34 (control)	8 (control)		17 (control)
Groups controlled for
Copy number	Yes	Yes	Yes	No	No	No
Gender	Yesb	Yes	Yesc	No	No	Yes (M)
Litter mates	Yes	No	No	No	Noa	d
Exclusion criteria	Yes	Yese	Yes	Nof	No	No
Onset (days)
Control	ND	95 ± 12	ND	161 ± 8f	ND	ND
G93A	ND	98 ± 11	ND	185 ± 5f	ND	ND
Significance		N.S.		<0.05
Survival (days)
Control	132	134 ± 8	127 ± 6	ND	210 ± 7.5	126 ± 3
G93A	135	148 ± 14	139 ± 3	ND	234 ± 13	135 ± 4
Significance	NS	0.039e	0.047c		N.S.	<0.05

^aAll animals used were second generation crosses, with much longer survival times (200 days), cf. first generation (∼130 days) which were high copy number G93A mutants.

^bAll treatment groups had equal numbers of males and females.

^cNumbers of males and females in control (five males, six females) and riluzole treatment (four males and seven females) were different; Student's t‐test used for comparison.

^dAll animals used were male and born within 4 days of each other; litter mate balancing not specified.

^eReported deaths due to non‐ALS symptoms; Student's t‐test used for comparison.

^fAll animals sacrificed at 199 days; none had reached end‐stage disease at this age. Age of onset measured by author from Figure 1 of reference.