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. 2018 Feb 19;61(5):2111–2117. doi: 10.1021/acs.jmedchem.7b01824

Figure 3.

Figure 3

HMBP ProPAgens mediate the specific lysis of bladder cancer cells by Vγ9/Vδ2 T-cells. (a) Human T24 urinary bladder carcinoma cell lines (target) were pulsed for 4 h with 10 nM of the indicated ProPAgens, media, or 10 μM zoledronate, then cocultured for 18 h with expanded Vγ9/Vδ2 T cells (effector) at the indicated target/effector ratios. Specific killing of target cells was measured by amine-reactive dead cell marker staining. Data display the mean of n = 2. (b) As in (a) showing the mean ± SD specific killing of T24 cells at 1:10 target/effector ratio for each indicated treatment, n = 2: (∗) P < 0.05; (∗∗) P < 0.01; determined by one-way ANOVA.