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. 2008 May 14;14(2):107–119. doi: 10.1111/j.1527-3458.2008.00044.x

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© 2008 The Authors. Journal Compilation © 2008 Blackwell Publishing Ltd

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Effects of tolperisone and lidocaine on recovery kinetics of sodium channels (Reprinted from Hofer et al. (2006) with permission.). (A) Voltage jump protocol that was used to elicit sodium currents: The oocyte membrane was held at −120 mV for 6 s to allow for recovery, then steady‐state inactivation was achieved using a first suprathreshold pulse. Recovery was assessed using a second suprathreshold pulse after a variable time interval at rest (arrows). (B) Original current recordings from Na_v1.5 under control conditions (left) and under the influence of 100 μmol/L tolperisone (right, upper) as well as under 300 μmol/L lidocaine (right, lower). Recovery time intervals were, (1) 10 ms; (2) 500 ms; (3) 5 s, and (4) 50 s, respectively. (C) Average recovery of Na_v1.8 for control conditions ( •), 100 μmol/L tolperisone (○), and 100 μmol/L lidocaine (). Bars represent S.E.M. Solid lines represent a biexponential fit. Time axis was split in two regions of different scaling to better visualize the domains of the fast and the slow recovery process. (D) As in C, but for Na_v1.5.

Inline graphic — Effects of tolperisone and lidocaine on recovery kinetics of sodium channels (Reprinted from Hofer et al. (2006) with permission.). (A) Voltage jump protocol that was used to elicit sodium currents: The oocyte membrane was held at −120 mV for 6 s to allow for recovery, then steady‐state inactivation was achieved using a first suprathreshold pulse. Recovery was assessed using a second suprathreshold pulse after a variable time interval at rest (arrows). (B) Original current recordings from Na_v1.5 under control conditions (left) and under the influence of 100 μmol/L tolperisone (right, upper) as well as under 300 μmol/L lidocaine (right, lower). Recovery time intervals were, (1) 10 ms; (2) 500 ms; (3) 5 s, and (4) 50 s, respectively. (C) Average recovery of Na_v1.8 for control conditions ( •), 100 μmol/L tolperisone (○), and 100 μmol/L lidocaine (). Bars represent S.E.M. Solid lines represent a biexponential fit. Time axis was split in two regions of different scaling to better visualize the domains of the fast and the slow recovery process. (D) As in C, but for Na_v1.5.