Table 1.

Pharmacokinetic parameters of resveratrol and its main metabolites

Dose	Treatment	Specie	Cmax	T max	t1/2	AUC	CLT	References
Oral resveratrol
Free resveratrol
25 mg	Single dose	Humans	<0.02 μM	1.0 h	–	–	–	96
25 mg	Single dose	Humans	∼0.03 μM	0.5 h	–	–	–	92
500 mg	Single dose	Humans	0.3 μM	0.8 h	2.9 h	1.0 μM·h	2.2 L/h	97
5000 mg	Single dose	Humans	2.4 μM	1.5 h	8.5 h	5.9 μM·h	4.9 L/h	97
0.1 mg/kg	Single dose	Rats	0.07 μM	0.5 h		–	–	98
0.1 mg/kg	15 days	Rats	0.03 μM	–	–	–	–	98
2 mg/kg	Single dose	Rats	2.4 μM	0.16 h	–	–	–	100
5 mg/kg	Single dose	Rats	0.1 μM	1.5 h	–	–	–	128
20 mg/kg	Single dose	Rabbits	1.1 μM	0.05 h	0.24 h	–	–	99
20 mg/kg	Single dose	Rats	1.2 μM	0.1 h	–	–	–	99
20 mg/kg	Single dose	Mice	2.6 μM	0.5 h	–	–	–	99
2.6 mg/kg	10 days	Mice	0.08 μM	–	–	–	–	99
50 mg/kg	Single dose	Rats	6.6 μM	0.3 h	1.5 h	7.1 μM·h	32.4 L/h/kg	101
4000 mg	Single dose	Mice	30.2 μM	0.5 h	–	–	–	102
Resveratrol glucuronide
500 mg	Single dose	Humans	1.8 μM	2.0 h	2.9 h	8.6 μM·h	282.7 L/h	97
5000 mg	Single dose	Humans	5.7 μM	2.0 h	7.9 h	44.2 μM·h	590.6 L/h	97
50 mg/kg	Single dose	Rats	105.2 μM	0.4 h	1.6 h	324.7 μM·h	0.7 L/h/kg	101
4000 mg	Single dose	Mice	534 μM	1.0 h	–	–	–	102
Resveratrol sulphate
500 mg	Single dose	Humans	5.1 μM	1.5 h	3.2 h	18.0 μM·h	131.2 L/h	97
5000 mg	Single dose	Humans	19.1 μM	2.1 h	7.7 h	137.6 μM·h	207.8 L/h	97
4000 mg	Single dose	Mice	386 μM	1.0 h	–	–	–	102
Intravenous resveratrol
Free resveratrol
15 mg/kg	Single dose	Rats	–	–	1.3 h	5.6 μM·h	11.7 L/h/kg	101
Resveratrol glucuronide
15 mg/kg	Single dose	Rats	–	–	1.5 h	38.7 μM·h	1.7 L/h/kg	101