Table 4.

Weighted* mean of baseline‐to‐end point placebo‐corrected mean differences in ON and OFF time for all studies in the meta‐analysis

Drug	No. of studies	No. of patients		Weighted mean
		Placebo	Drug	difference, h	95% CI
ON Time
Entacapone	4	301	389	1.02	0.62–1.39
Tolcapone†	4	209	333	1.86	1.29–2.42
OFF Time
Entacapone	4	221	389	0.68	0.22–1.13
Tolcapone†	4	209	333	1.60	1.10–2.10

*Weighted, in this context, refers to a meta‐analytic procedure that assigns a multiplier to each study based on its quality rating, such that the results from higher‐quality studies are accorded more weight in determining the overall mean.

^†Includes 100 mg t.i.d. and 200 mg t.i.d. arms of the studies by Adler et al. (Adler et al. 1998) and Bass et al. (Baas et al. 1997).