Table 5.

Summary of all‐cause withdrawal rates, Peto odds ratios,* and 95% CIs in analyzable trials

Drug	Number of studies	Withdrawals n/N (%)		Peto
		Placebo	COMT	odds ratio	95% CI
Entacapone	5	67/441	152/693	1.40	1.02–1.93
		(15.2%)	(21.9%)
Tolcapone	2	8/105	10/175	0.75	0.09–2.74
		(7.62%)	(5.71%)

Data from Deane KH (Deane et al. 2004).

*A specific statistical method for obtaining odds ratios in meta‐analyses (Berlin et al. 1989).