Table 4.
Age of first exposure to combination antiretroviral therapy (cART)1 by dental and periodontal outcomes2 among 205 perinatally HIV-infected youth youth ever exposed to cART participating in the Oral Health study in the AMP/PHACS3
| < 2 yrs N = 82 | 2 to 5 yrs N = 85 | 6+ yrs N = 38 | P-value4 | |
|---|---|---|---|---|
| DMFS score | ||||
| - Mean (SD) | 5.5 (6.2) | 9.5 (11.5) | 13.8 (17.2) | 0.001 |
| - Median (Q1, Q3) | 4 (0; 9) | 6 (2; 13) | 8.5 (4; 19) | |
| DMFT score | ||||
| - Mean (SD) | 3.9 (4.0) | 5.6 (5.0) | 7.5 (5.8) | < 0.001 |
| - Median (Q1, Q3) | 3 (0; 6) | 4 (2; 8) | 6 (4; 11) | |
| DS | ||||
| - Mean (SD) | 2.3 (3.7) | 3.3 (7.8) | 4.4 (8.2) | 0.27 |
| - Median (Q1, Q3) | 1 (0; 3) | 1 (0; 3) | 1.5 (0; 5) | |
| DT | ||||
| - Mean (SD) | 1.9 (2.7) | 2.2 (3.7) | 3.0 (4.0) | 0.20 |
| - Median (Q1, Q3) | 1 (0; 3) | 1 (0; 2) | 1.5 (0, 5) | |
| Teeth with 2-6 BOP sites | ||||
| - Mean (SD) | 7.4 (7.2) | 9.9 (7.0) | 11.3 (8.6) | 0.01 |
| - Median (Q1, Q3) | 5 (2; 11) | 8 (4.5; 15) | 11.5 (3; 18) | |
1
cART was defined as any regimen containing at least three drugs from at least two drug classes.
2
DMFS/T: decayed-missing-filled-surface/teeth score; DS: number of decayed surfaces; DT: number of teeth with caries; BOP: bleeding on probing
3
Adolescent Master Protocol (AMP) of the Pediatric HIV/AIDS Cohort Study (PHACS); Note: 4 participants were not exposed to cART
4
Kruskal-Wallis Test