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. 2018 Mar 2;2018(3):CD012243. doi: 10.1002/14651858.CD012243.pub2

Summary of findings 4. Morning bright light versus afternoon bright light for improving mood and alertness in daytime workers.

Morning bright light versus afternoon bright light for improving mood and alertness in daytime workers
Patient or population: daytime workers
 Setting: offices
 Intervention: morning bright light
 Comparison: afternoon bright light
Outcomes Anticipated absolute effects* (95% CI) Relative effect with morning bright light
 (95% CI) № of participants
 (studies) Quality of the evidence
 (GRADE)
Risk with afternoon bright light Risk with morning bright light
Alertness
 assessed with: visual analogue scale
 Scale from: 0 to 100 (better)
 follow‐up: 2 weeks Mean 59 (SD 23) Mean 66 (SD 25) MD 7 higher
 (−10.18 lower to 24.18 higher) 30
 (1 RCT) ⊕⊕⊝⊝
 Low1,2
Mood
 assessed with: SIGH‐SAD (≥ 50% reduction of SIGH‐SAD)
 follow‐up: 2 weeks 426 per 1000 688 per 1000
 (345 to 1376) RR 1.60
 (0.81 to 3.20) 30
 (1 RCT) ⊕⊕⊝⊝
 Low1,2
Adverse events (frequency)
 follow‐up: 2 weeks 712 per 1000 375 per 1000
 (349 to 1000) RR 0.53
 (0.26 to 1.07) 30
 (1 RCT) ⊕⊕⊝⊝
 Low1,2
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: confidence interval; MD: mean difference; RCT: randomised controlled trial; RR: risk ratio; SIGH‐SAD: Structured Interview Guide for the Hamilton Depression Rating Scale‐Seasonal Affective Disorders Version.
GRADE Working Group grades of evidenceHigh quality: We are very confident that the true effect lies close to that of the estimate of the effect.
 Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
 Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect.
 Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect.

1 We downgraded the level of evidence with one level, i.e. from high to moderate quality, due to risk of bias (the authors did not fully describe their randomisation method nor how or if they employed allocation concealment).

2 We downgraded the level of evidence with one level, i.e. from moderate to low quality, due to imprecision (a small sample size and a wide confidence interval including a null effect).