Summary of findings 2. A boost of inhaled corticosteroids compared to usual care for autumn asthma exacerbations in children.
| A boost of inhaled corticosteroids compared to usual care for autumn asthma exacerbations in children | ||||||
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Patient or population: autumn asthma exacerbations in children Setting: community Intervention: a boost of inhaled corticosteroids Comparison: usual care | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Risk with usual care | Risk with a boost of inhaled corticosteroids | |||||
| Exacerbations assessed with: hospital admission or oral corticosteroid requirement asthma stages 2‐4 follow‐up: 90 days | 127 per 1000 | 111 per 1000 (44 to 251) | OR 0.86 (0.32 to 2.30) | 173 (1 RCT) | ⊕⊕⊕⊝ MODERATE 1 | Absolute effects calculated using control risk of 12.7% from Teach 2015a. |
| Adverse events assessed with: number of children experiencing 1 or more adverse events asthma stage 2‐4 follow‐up: 17 to 19 weeks | 533 per 1000 | 434 per 1000 (280 to 603) | OR 0.67 (0.34 to 1.33) | 176 (1 RCT) | ⊕⊕⊕⊝ MODERATE 1 | |
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; OR: odds ratio; RCT: randomised controlled trial | ||||||
| GRADE Working Group grades of evidence High quality: We are very confident that the true effect lies close to that of the estimate of the effect. Moderate quality: We are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low quality: Our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low quality: We have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. | ||||||
1Downgraded once for imprecision because few children studied.