3. Included studies with data on oestrogen dose.

Study	Design	Outcome	Non‐use Event (n)/Total (n)	20 µg E2 Event (n)/Total (n)	30 to 49 µg E2 Event (n)/Total (n)	≥ 50 µg E2 Event (n)/Total (n)
Chang 1999	Case‐control	Ischemic stroke	42/188	—	—	9/23
Heinemann 1998	Case‐control	Ischemic stroke	96/353	—	—	15/38
Lidegaard 2012a	Cohort	Both	*	*	*	*
Rosenberg 2001	Case‐control	Myocardial infarction	591/3301	—	—	4/7
Shapiro 1979	Case‐control	Myocardial infarction	205/1812	—	—	18/107
Sidney 1998	Case‐control	Myocardial infarction	255/1159	—	—	2/7
Tzourio 1995	Case‐control	Ischemic stroke	25/135	2/7	30/76	8/15

Abbreviations: µg: micrograms; E2: ethinylestradiol; n: number.

* Adjusted effect estimates extracted