Cingozbay 2002.

Methods	no washout required because no participant was receiving any medication or dietary restriction 3‐month before and after trial
Participants	20 men and women with hyperlipidaemia age 31‐53 years BMI 25.9 patients with other causes of peripheral insulin resistance were excluded Fluvastatin 40 mg/day baseline TC : 7.5 mmol/L (290 mg/dL) Fluvastatin 40 mg/day baseline triglycerides: 5.9 mmol/L (523 mg/dL)
Interventions	Fluvastatin 40 mg/day
Outcomes	per cent change from baseline at 12 weeks of serum TC and triglycerides
Source of Funding	unknown
Notes	LDL‐C and HDL‐C lipid data were not included in the efficacy analysis SDs were imputed by the method of Furukawa 2006
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Controlled before and after design
Allocation concealment (selection bias)	High risk	Controlled before and after design
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Lipid parameter measurements unlikely influenced by lack of blinding
Blinding of outcome assessment (detection bias) LDL‐cholesterol	Low risk	Lipid parameters were measured in a remote laboratory
Blinding of outcome assessment (detection bias) WDAEs	High risk	No comparison possible
Incomplete outcome data (attrition bias) All outcomes	High risk	No data for LDL‐C
Selective reporting (reporting bias)	High risk	LDL‐C outcome was not reported
Other bias	Unclear risk	Source of funding was not reported