Dergunov 2003.

Methods	8‐week dietary run‐in period 16‐week before and after trial
Participants	67 men with controlled hypertension LDL‐C > 4.1 mmol/L (159 mg/dL) TG 0.49‐3.26 mmol/L (43‐289 mg/dL) exclusion criteria: none reported Fluvastatin 20 mg/day baseline TC : 6.93 mmol/L (268 mg/dL) Fluvastatin 20 mg/day baseline LDL‐C : 5.07 mmol/L (196 mg/dL) Fluvastatin 20 mg/day baseline HDL‐C : 1.06 mmol/L (41 mg/dL) Fluvastatin 20 mg/day baseline triglycerides: 1.765 mmol/L (156 mg/dL)
Interventions	Fluvastatin 20 mg/day for 0‐4 weeks Fluvastatin 20‐40 mg/day for 4‐8 and 8‐12 weeks Off fluvastatin for 12‐16 weeks
Outcomes	per cent change from baseline at 4 weeks of serum TC, LDL‐C, HDL‐C, and triglycerides
Source of Funding	partially by Russian Foundation for Basic Research grant 01‐04‐48140
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Controlled before and after design
Allocation concealment (selection bias)	High risk	Controlled before and after design
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Lipid parameter measurements unlikely influenced by lack of blinding
Blinding of outcome assessment (detection bias) LDL‐cholesterol	Low risk	Lipid parameters were measured in a remote laboratory
Blinding of outcome assessment (detection bias) WDAEs	High risk	No comparison possible
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants were included in the efficacy analysis
Selective reporting (reporting bias)	Low risk	LDL‐C outcome was reported
Other bias	Unclear risk	Partially funded by Russian Foundation for Basic Research grant 01‐04‐48140