Kowalski 2006.

Methods	4‐week dietary run‐in period 6‐week before and after trial
Participants	35 men and women with mixed hyperlipidaemia age 35‐47 and BMI >25, low physical activity and family history of CHD 18 participants received fluvastatin TC > 300 mg/dL (7.76 mmol/L) LDL‐C 170 mg/dL (4.4 mmol/L) TG > 200 mg/dL (2.26 mmol/L) exclusion criteria: childbearing potential no baseline values
Interventions	Fluvastatin 40 mg/day Atorvastatin 10 mg/day
Outcomes	per cent change from baseline at 8‐12 weeks of serum TC, LDL‐C, and triglycerides
Source of Funding	unknown
Notes	Atorvastatin group was not included in the efficacy analysis SDs were imputed by the method of Furukawa 2006
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Controlled before and after design
Allocation concealment (selection bias)	High risk	Controlled before and after design
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Lipid parameter measurements unlikely influenced by lack of blinding
Blinding of outcome assessment (detection bias) LDL‐cholesterol	Low risk	Lipid parameters were measured in a remote laboratory
Blinding of outcome assessment (detection bias) WDAEs	High risk	No comparison possible
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants were included in the efficacy analysis
Selective reporting (reporting bias)	Low risk	LDL‐C outcome was reported
Other bias	Unclear risk	Source of funding was not reported