Pinon 2002.

Methods	4‐6 week washout period 6‐month before and after trial
Participants	27 men and women with polygenic hypercholesterolaemia 20‐65 years old serum cholesterol >240 mg/dL; LDL‐C > 160 mg/dL; triglycerides < 200 mg/dL (serum cholesterol > 6.21mmol/L; LDL‐C > 4.14 mmol/L; triglycerides < 2.26 mmol/L) exclusion criteria: renal and hepatic dysfunction, cancer, inflammatory or infectious diseases,, previous ischaemic event, thyroid hormone alterations obesity, chronic alcoholism, diabetes mellitus, hypertension or pregnancy and surgery within 3 months of study
Interventions	Fluvastatin 40 mg/day
Outcomes	per cent change from baseline at 3 months of serum TC, LDL‐C, HDL‐C, and triglycerides
Source of Funding	unknown
Notes	SDs were imputed by the method of Furukawa 2006 except for triglycerides which was determined from the P value
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Controlled before and after design
Allocation concealment (selection bias)	High risk	Controlled before and after design
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Lipid parameter measurements unlikely influenced by lack of blinding
Blinding of outcome assessment (detection bias) LDL‐cholesterol	Low risk	Lipid parameters were measured in a remote laboratory
Blinding of outcome assessment (detection bias) WDAEs	High risk	No comparison possible
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants were included in the efficacy analysis
Selective reporting (reporting bias)	Low risk	LDL‐C outcome was reported
Other bias	Unclear risk	Source of funding was not reported