Weiss 1998.

Methods	8‐week dietary‐stabilisation drug washout period 12‐week before and after trial
Participants	1776 men and women 18‐75 years old with moderate hypercholesterolaemia LDL‐C ≥150 mg/dL (3.88 mmol/L) exclusion criteria: triglycerides ≥ 350 mg/dL (3.95 mmol/L) SGOT > 1.2 X ULN type 1 diabetes mellitus, participants were 40% above ideal weight Fluvastatin 20 mg/day baseline TC : 6.81 mmol/L (263 mg/dL) Fluvastatin 20 mg/day baseline LDL‐C : 4.59 mmol/L (177 mg/dL) Fluvastatin 20 mg/day baseline HDL‐C : 1.29 mmol/L (50 mg/dL) Fluvastatin 20 mg/day baseline triglycerides: 2.06 mmol/L (182 mg/dL)
Interventions	Fluvastatin 20 mg/day for 0‐6 weeks Fluvastatin could be titrated to 40 mg/day for 6‐12 weeks
Outcomes	per cent change from baseline at 6 weeks of plasma TC, LDL‐C, HDL‐C, and triglycerides
Source of Funding	unknown
Notes	the titrated time period of 6‐12 weeks was not included in the analysis
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Controlled before and after design
Allocation concealment (selection bias)	High risk	Controlled before and after design
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Lipid parameter measurements unlikely influenced by lack of blinding
Blinding of outcome assessment (detection bias) LDL‐cholesterol	Low risk	Lipid parameters were measured in a remote laboratory
Blinding of outcome assessment (detection bias) WDAEs	High risk	No comparison possible
Incomplete outcome data (attrition bias) All outcomes	Low risk	8.3% participants were not included in the efficacy analysis
Selective reporting (reporting bias)	Low risk	LDL‐C outcome was reported
Other bias	Unclear risk	Source of funding was not reported