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. 2018 Mar 15;2018(3):CD011276. doi: 10.1002/14651858.CD011276.pub2

Comparison 1. Systemic treatment plus surgery versus systemic treatment.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Overall survival 2 624 Hazard Ratio (Random, 95% CI) 0.83 [0.53, 1.31]
2 Overall survival ‐ HER2 status 2   Hazard Ratio (Random, 95% CI) Subtotals only
2.1 HER2‐positive 2 192 Hazard Ratio (Random, 95% CI) 0.85 [0.48, 1.50]
2.2 HER2‐negative 2 421 Hazard Ratio (Random, 95% CI) 0.84 [0.50, 1.40]
3 Overall survival ‐ ER status 2   Hazard Ratio (Random, 95% CI) Subtotals only
3.1 ER‐positive 2 426 Hazard Ratio (Random, 95% CI) 0.83 [0.48, 1.42]
3.2 ER‐negative 2 200 Hazard Ratio (Random, 95% CI) 1.04 [0.70, 1.55]
4 Overall survival ‐ only bone metastasis 2 226 Hazard Ratio (Random, 95% CI) 0.91 [0.49, 1.69]
5 Progression‐free survival 2   Hazard Ratio (Random, 95% CI) Subtotals only
5.1 Local progression‐free survival 2   Hazard Ratio (Random, 95% CI) 0.22 [0.08, 0.57]
5.2 Distant progression‐free survival 1   Hazard Ratio (Random, 95% CI) 1.42 [1.08, 1.86]